I used to drink on meds, but I don't think its a good idea. I remember one time when I was on Seroquel XR I had, I think 3 beers at a wedding and I was super drunk and throwing up in grocery bags in the car the whole way home and up forever throwing up. I was probably lucky it wasn't worse because I was also on other meds, including Klonopin. I don't drink at all now. Plus, it kind of defeats the purpose of the meds.