Yep, looks like you should ask your p-doc before trying the Super Sleep since you are taking Dffexor/venlafaxine. I have taken it with Cymbalta and didn't have any problems, but venlafaxine has a much greater effect on serotonin receptors than Cymbalta, plus I don't take a high dose of Cymbalta. You don't want serotonin syndrome, for sure.

What I have read about Ambien/zolpidem says that it doesn't tend to disrupt sleep architecture (you'll get enough deep sleep). That's different from the info. in metamorphosis17's post.

I didn't ask if you tend to wake up in the middle of the night or if you tend to have trouble falling asleep in the first place. If you wake up in the middle of the night, the extended release pill, Ambien CR, will probably work better.

There are other "z" sleep meds like Lunesta and Sonata that are weaker than Ambien and there's trazodone, which doctors tend to like. None of those made me sleepy the least bit, but they might work for you.

I haven't tried Rozerem/ramelteon so I have no comments about it.

I have fibromyalgia as well as depression. I used to take 375 mg/day Effexor for fibromyalgia pain and depression before Cymbalta was available. It gave me extreme insomnia. I would stay awake until the sun started coming up much of the time unless I took Ambien. I didn't take it 100% of the time, but I probably took it about 90% of the time. Sometimes it would seem like I had developed a tolerance to the 10 mg dose of Ambien, so I would stop it for a month and then it would work again.

I never got any "withdrawal" type effects if I stopped Ambien. Some people say they do. I don't count insomnia as a rebound effect, since I wasn't sleeping before I started taking it.

I don't "casually" recommend that someone take prescription sleep meds regularly, but if you're taking 450 mg Effexor, your case of depression is not "casual" and if your doctor doesn't see any option other than for you to stay with that med, you need a way to get some sleep.

I hope you find something that works for you.