I'm on Seroquel - 400 mg (200 twice daily) and I gained a little bit of weight on it, but cutting out sweets (substitute fruits for sweets to curb the cravings) and increasing exercise helped that.

I was on Depakote - 1000 mg (500 twice daily) for two months and gained 10 pounds even though I couldn't eat anything from the nausea that I constantly felt. I am working on losing that weight, not that I'm off the Depakote, but it's not coming off as easily as the weight from the Seroquel did.

Some things I did to help - cut out most sweets (I'll still indulge in a piece of chocolate every now and again, but try to stay away), cut out sodas and sub with ice water or water with flavoring or herbal teas (iced or hot). I also have some food issues, so I make a weekly menu which includes all meals and snacks and try to just stick to that. I also increased my exercise and try to get in at least a 3 mile walk/run each day.