I had to take a year off due to a life-threatening medical illness, although I also have an eating disorder and depression that did need to be addressed. I went back to work about 9 months ago, and I went back to work (for now anyway) to an easier job than what I was doing and only part-time. If that's something you can swing, I would recommend part-time to begin with if it'll have been a while since you worked. It took me a while to get used to the whole routine/working thing again, and I still have a lot of health issues so a lot of drs appts and am still struggling with the ED and depression. I plan to start looking for a full-time job in my previous profession very soon, but it was great to have a year to kind of adjust to working again.