I was prescribed Latuda as an enhancer with Zoloft last July for depression and I don't have Bipolar. It did work to quickly to take away the depression. However, it greatly increased my appetite and I gained 20 pounds really quickly and my depression came back rapidly after my body became used to it. I just tapered off of it and the withdrawal has been awful. Except for the weight gain, I think it worked okay while I was on it. Good luck!