Thanks, you guys, for your feedback -- I'm afraid I haven't been around for a bit. I was on the XR for two years after being on the regular for twelve years... and I noticed that the XR worked for some symptoms but not others. So now I'm back on the regular S, today's the third day, and I've been feeling a lot better... I take 400mg at bedtime and it improves my sleep quality, then 200mg in the a.m. and 200mg late afternoon. The difference is subtle but noticeable -- I feel happier, less anxious and lighter inside.

I guess everyone reacts differently to different drugs... even different versions of the same drug. Fortunately, I have been able to control my weight on Seroquel after experiencing weight gain, though admittedly I put a lot of effort into exercising a lot and following a healthy diet.

I just hope the improvement I'm noticing on the regular S will remain... it's too soon to say, but I have my fingers crossed. :-)