Well, I'm not an overly conservative type, and I get that mj is a fact of life, for many. However, it's noticeably affecting her mood. Like some bodies reject long term medications, I honestly wonder if your wife's ability to handle it, waned? Or it's a rebound effect possibility? Just thinking out loud here, since it's a medicinal hot topic..

Or.....does she stuff down anger and have passive aggressive moments? Is there trauma, ptsd?

Is she wanting to find the root cause and change these moments? No sense if it's changing for anyone else, but herself...