I have been on Seroquel twice now at 400 mg both times. It has helped tremendously with my BP and my sleep problems. I use to drink red bulls to wake me up. I got off of them and drink the V8 Fusion Energy that has the same amount of caffeine as a red bull, but it's green tea which is better for you. I have been weening off of Seroquel with the assistance of my pdoc because I am pre-diabetic and have high triglycerides because of the Seroquel. Right now I am at 200 mg. Everyone reacts differently with Seroquel, I need the caffeine, others adjust to it.