I have been slowly coming off of Seroquel with the assistance of my pdoc. The first week I went from 400 to 300 and was miserable. I stayed on 300 for a month and then told my pdoc I would like to go down 50 mg at a time every two weeks. It doesn't even matter my digestive track is a mess. I'm currently at 200 mg. I've been on probiotics forever. I'm also on fish oil, I don't know if that helps, I thought I would mention it though. Has anyone gone thru this that came off of Seroquel, and did anything help cause I have a ways to go and this is not fun.