AD's are unpredictable, they can actually work for some, for others have adverse effects and ridiculous side effects. About the only AD I can tolerate is wellbutrin which is not your typical AD at all. Unfortunately it does nothing for my depression and increases my anxiety. I still take it only because it does help relieve some of my fatigue from other meds. I thought I found a winner with Zoloft, the first time I tried it and after I got use to it's terrible side effects it at least helped my anxiety but also did nothing for my depression. The last time I tried zoloft it was like a acid trip and not a good one either!

I just started taking Lamictal, only up to 50mg so far, while it does seem to help in stabolizing my moods, it too does very little for my depression! Before Lamictal I was on Seroquel, which was about the same as Lamictal but gave me extreme dry mouth and weight gain and the hang over effect. That's why we switch to Lamictal which has very little side effects, slight dry mouth and tired a little. I'm waiting for Abilify to go generic as that was the best I've tried so far. The hardest for me is my depression and anxiety. About the only possible advantage I have if you want to call it that, is my depression is atypical and or mixed, so I'm not depressed 24/7, I get some breaks but it's always never far off.

Good Luck!