I think that our bodies just adjust to meds and eventually they don't work as well. That happened to me with every until I started an MAOI about 6 years ago. I've been on Seroquel for 8 years I think and have had to increase the dosage over time to the point that my current episode caused it to go really, really high. The disorder does progress at least in some people but I think that's at least partially med burn-out.

I have never taken Invega because risperidone (which is related) causes me to have high blood pressure. We tried the risperidone I think 3 times because it was so frustrating; it worked for me but the blood pressure thing wasn't healthy at all. My dr said good things about it once before realizing I couldn't take it.

You picked 2 meds that aren't my best experiences. With Abilify my psychiatrist said she had a feeling I might be sensitive and started me at a teeny dose, 2.5 mg if i remember. The day after I took it I kept falling down. r. It also caused double vision and akathesia, both of which took several weeks to resolve. I was off work about a month.

Zyprexa was another story and in a way it didn't get a fair trial but I'm not anxious to go on it and my psychiatrist seems to thing it really did not work and is not an option. Anyway with it I had akathesia from something given during surgery. So in trying to treat me at home we had me taking a lot of medication. Zyprexa was one of them and at 5 and 10 mg both taken for probably about a week I did not become any less agiated, much less sedated or all the things Zyprexa is suposed to do. So it never got a chance to try a normal episode and see what happens then. I suppose it might be re-tried but since tha's never come up and much nastier drugs have I think that it just must not work for me. I'd try it again if I had to but honestly I'm kind of glad it didn't work because I don't need the weight gain.