I feel your pain. I gained 50 lbs on Risperdal and over 100 on Seroquel. I've lost quite a bit now but it was awful (this started in my mid 20's). Seroquel worked better than Risperdal for my obsessive thoughts, but I was forced to cut down from 400 to 100 because of metabolic affects, blood sugar and cholesterol (and not given a choice about it, which was awful after 7 yrs on this med).