I do know that when I have an upset belly or gut discomfort I'm not in the best of moods. It's bad that I have an ulcer now that sometimes makes it feel like someone is twisting a knife in my back, or a low level throbbing ache in my chest constantly. I've been taking OTC acid reducers which has helped the acid reflux which I think caused it. It's feeling better now and I'm in a chirpy mood.