Try to consider how it will affect those who love you and indeed depend on you. And where will this desition take you. If you make x desition, will it take you in the direction you need to go?
Are you willing to hurt the ones you love?
Is it responsible?
Are the consequences of it most likely to cause others to be hurt, will they be able to forgive you? Sometimes in life one can not avoid hurting others. But it always comes with a high price.
Are you willing to pay the price?
Or let someone else pay the price, emotionally that is.
Just keep in mind that you are part of something bigger than yourself. A family, a group, a society. How important is individual gratification, and how much should we give up for others?
I find that when I put a little focus on that, it makes it easier to make up my mind. But of course it depends on the magnitude of what ones wishes are. Taking a weekend-trip by yourself is wastly different from selling your house and move to Hawaii, for instance
The older I get, the more do I realize how imporant it is to bring others into my thought-process.
Others can have very sound advice, and help me see the consequences of my actions.

For me the problem has always been that I don`t think clearly about consequences. Am I willing to pay the price for my actions? Was it worth it?