I had a bit of anxiety the first few days, and I do feel a little more anxious than I was feeling before. I should note that I did have some pretty strong negative reactions to the last couple meds I was on--Prozac and Effexor, with Prozac making me much more anxious and Effexor making me much more depressed. So Cymbalta might just not seem as bad to me by comparison...

I take mine in the morning with breakfast--maybe try that, since it's causing you sleep problems? You could gradually move earlier in taking it over a couple days if you don't want to try changing the time too quickly. The lack of good sleep is probably contributing.

Or it could just be, for whatever reason, that this isn't the right medication for you now, even though it worked for you before. Could be hormonal, brain chemistry, other reasons. If you're still feeling this way Tuesday, definitely call your p-doc!