I think you're making a mistake here, thinking that antidepressants are the only thing that might work for a "serious" case of depression.

You can think of it this way. Suppose you have a severe vitamin D deficiency or a vitamin B12 deficiency or hypothyroidism or a gluten allergy or any of the other common problems listed in my previous post. If you have any one of these, do you really think that antidepressants are going to solve your problem? You might be assuming that if there is something important that should be checked, your M.D. will check for it. This is a very reasonable assumption - it's just not true! You've usually got to specifically ask for these things. People sometimes think that because they've had a blood test, these things must have been checked. This is also not true.

For SAM-e specifically, see the huge effect it had on the poster ItGoesOn in the depression success stories section.

- vital