XR SHOULD be better for sleepiness in the daytime. Of course people react differently and so what SHOULD be sometimes isn't. I begged to change to it from regular Seroquel the minute it came out because I heard it was for people exactly like me: on a higher dose and having excessive daytime sleepiness. I was on it before the pharmacies had it stocked even though my pdoc normally doesn't let me be the first to try new meds because I'm very sensitive.It made a big difference for me. But I was SO sedated anyway; I was also taking 3200 mg of Depakote ER and ativan at night and PRN and maybe something else sedating. So that may be what helped me; any drop in a desert kind of thing. I used provigil/nugivil with it when my body was used to it (I did with regular seroquel too) and that was helpful although I had to closely self-monitor for side effects. But really until I went on an MAOI and came off Depakote I had a really hard time with being extremely sedated and took advantage of flex time except that 2 jobs in a row started taking it away from me for reasons that were never made clear. I never could figure out why my doing paperwork later in the evening was a big deal. But it was and so I had a lot of trouble at those 2 jobs and was fired from both. Then I got the MAOI and life was wonderful because it is stimulating and I was finally AWAKE. Until I had surgery with some brain damage from a bad reaction to something and then just became so untreatable I had to be on enormous doses of meds and the MAOI no longer helps me wake up early or fall asleep early. I dream that someday that schedule will come back but I don't think it is likely unless an amazing new drug comes along.

I've found this chart helpful in the past although like everything some meds that don't do better than placebo do work for some people; I'm on 2 of those and they do help me.

Mood Stabilizers | PsychEducation

Everything on that page is good information that gives me detail than the chart but I've used the chart as a handy referene for years and it's a place to start with "I'm not taking that because____". Not that it's done a lot of good for me; trial and error is all that works for me. I just gave blood to a clinical trial trying to find blood tests to help determine best treatments and how the body is processing meds. In a few months I'll do it again and this time get my personal results which will be very interesting.