I started trying to get on it for migraine control in 2013. Because it is sedating and I was already on a lot of sedatives we didn't know if I manage to take it and get to a goal of 100 mg without being unable to get out of bed. I tried for months and while it immediately had some psych effect it was impossible to tolerate 50 mg. I tried cutting to 37.5 and got paranoid and agitated so was lowed back to 25 mg where I still am now. It seems unlikely that it does much at such a low dose but when I missed several doses when I ran out during a snowstorm my mood dipped so we continue it. Trying to increase again is one option for my current situation (on 1500 mg of Seroquel plus a bunch of others and not sedated) but because of the paranoia I think we decided not to do that. It never touched my migraines .