Miss U - I really have not seen anyone who has used successfully Remeron™ (mirtazapine) as their primary antidepressant. Where I practice as a pharmacist I see it used as an add-on antidepressant for those who have had a partial response to the SSRIs. The only instances where I see it used by itself is when it is used as a sleeping pill; but you are probably using the Seroquel™ (quetiapine) to aid in falling asleep.

Have you tried any other antidepressants, and if so, which ones. - Cam