For a very long time, I was on Wellbutrin SR with a dosage of 150 mgs once a day. I found this helped balance out my depressive state and not aggrivate my manic or anxiety state too much. However, just recently my new pdoc switched me to Wellbutrin XL at 150 mgs once a day and I felt like I had to be peeled off the ceiling most days... swinging between extreme mania and high anxiety. I reported this to my pdoc and he agreed to knock down the dosage to 100 mgs and go back to Wellbutrin SR.

Since this change is very new, I have yet to see if this will be helpful or harmful.