I have asthma and bipolar, and oral prednisone makes me manic. I have to take it every few years when my asthma gets out of control, and the only thing to do is increase my APs until the steroids are out of my system. I don't use steroid inhalers because my case is mild/intermittent and I hardly even use my rescue inhaler. But when it gets bad, it gets bad, and the only thing that keeps me out of the hospital is prednisone. You have to treat the breathing as the first priority, and BP comes in second unfortunately.