Genevieve - I haven't heard of any connection between electrolyte levels and seizures; although I am not certain. I'm a community pharmacist and have never worked in a hospital, so I never really get to see an electrolyte panel, let alone be able to read one.

I have no idea when seizure risk is the highest; I have not seen a study that measured those variables. In the two cases that I have experience with, the seizures arose early, within the first couple weeks of therapy. If this is typical, I don't know. Since the drug company's drug monograph for Wellbutrin™ (bupropion) the risk of seizuring due to the medication increases with increasing dose. This would suggest to me that the risk of seizures is dose-related.

As for body chemistry, the body is fairly resilient. Feed it properly and it bounces back.

I'm sorry that I don't have many answers for you. - Cam