I took mushrooms and acid many years ago with no negative consequences but that was also before I had my first breakdown (PTSD related) and later was diagnosed BP also. Now I don't think I would risk taking them as you are basically inducing psychosis and it could do all sorts of weird things to my brain chemistry. It is a risk. I must admit I would still be tempted as my previous experiences with those drugs were amazing. It is going to affect everyone differently so it is impossible to know how you will react. If you do do it make sure you are around safe, straight people who can look after you.