All I can say is I can relate to what you are going thru as do so many others. I was diagnosed eight years ago and I've done the med merry go round so many times. With trying new meds you have to wait so long to even see if they are working. Right now I'm laying in bed and I can't sleep. It's the first night off of my Seroquel and the Trazadone is not helping me sleep. The last few weeks I've been questioning whether I'm going into a mixed episode. This happened last year when I came off Seroquel but I don't want to be diabetic anymore from this medicine. You're right, it is a constant roller coaster that never stops. I just wanted to let you know you are not alone. Keep working with the meds. If you don't like your pdoc get a new one. I waisted my first seven years of this diagnosis with a horrible pdoc and now have a great one that is really trying to help me. Keep moving forward, and keep coming back here for support because we all know what you are going through.