Yes, I do take Zoloft also and we didn't discuss it. Mostly we focused on the Lamictal because I had sent him an email about me feeling like I was taking too many medications on too high of doses. He promised that he was doing all he could to get me on the lowest amount of meds in the timeframe alloted by my illness (basically). He told me that the Vyvanse also has antidepressant properties.