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Several months (up to/over a year maybe) for the lows, much much much much shorter (week or so as shortest) for the highs (never fully manic) . Not sure how it is now with my current cocktail though, currently leveled out.
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Diagnosis:
Bipolar Disorder II
Anxiety Disorder
OCD
Meds:
Lithium
Lamictal
Seroquel
Zaprexa
Oxazepam
Lots of misc that I wont list, but feel free to ask about above 
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