I had that exact experience with Latuda I told my prescriber that I was done after I ran out over a weekend and could not get it till tuesday (pharmacy doesn't keep it stocked so it takes a day) that was over a week ago and I feel great I can exercise, my sleep is better, my eating habits have improved. Don't get me wrong it snapped me out a pretty brutal mixed episode and I am apprehensive about cycling again. I'm still on lithium so feel "protected" against mana, but I am very concerned about this coming winter and being on my own against the depression which can become mixed. Everybody is different so what worked for me may not work for you.