I'm not sure. My first thought was deciding to have my leg amputated, but that wasn't much of a choice (it really was the only solution.. and the doctors threathened to have my parents declared unfit guardians if they disagreed (I was 15, so they still had a say) and to have me declared incompetent and legally unable to make my own decisions if I disagreed) and it's the best choice I've ever made. It was the biggest decision, but not per se the most difficult. So I really don't know.