May I ask what diagnosis you were given when you were taking meds? If it's plain vanilla depression, you might try Wellbutrin alone to see if that helps. It won't disturb your sex life, but it may make you jittery and give you insomnia.

I think it's great that Sam-E works for you. I have taken it before and liked the way it made me feel, but at the time, there seemed to be quality control issues or something, because one bottle would work great then then next one (same brand) didn't seem to do anything.

May I ask what brand you like? Does it still have to be taken in the morning before you've eaten anything? (It's been years since I took it, and at that time, the formulation was still kind of "delicate".)

Your exercise and weight loss are a significant accomplishment, and I completely understand why you don't want to jeopardize that.