I have felt the same as all of you. Even now my life is a mess and I have thoughts that I cannot fix it. If I did find a permanent answer to my chronic depression its unlikely that exactly what worked for me will work for you. What I think I can suggest is that if what you are trying now is not working see if you can find it within you to try something else.

For myself lately I have been trying to be mindful that I have not tried everything. Obviously there are some things with zero evidence and others that I find ridiculous. I am not referring to anything without evidence here.

I think it is important to not rule out an entire field which may be of help. For example, for me to state with certainty that exercise cannot help me would be to rule out that it will ever under any circumstance and using any combination would be of any help. The same applies with medications.