2 weeks is not long enough for anti depressant medications to take much effect. I find with almost all antidepressants I tried that I get worse before I get better. Wellbutrin is kind of stimulating and does tend to reduce appetite. But the side effects usually fade with a bit of time. The best thing to do really is to encourage him to continue and give the current strategy a chance to work. If it does not work then change strategy. His medical practitioner should he made aware of the sleep and weight issues. I know how it is. Depression, particularly chronic depression, is right up there with the worst things that can happen to you.

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