What medication is it? How long have you been taking it?

I've had the "restless" feeling, like I have to do something, but don't know what. Wellbutrin can cause this for me.

When I took Paxil and Proxac without a stabilizer, I felt like I was going to jump out of my skin. It caused not just restlessness, but actually made me manic. I Constantly had to do things, but my attention span and follow through was terrible, so I'd start tons of things but not finish them.

So the short answer to your question is YES, medications can cause restlessness. Definitely discuss this symptoms with your doctor.