Usually with the latuda I would take take it two hours before sleeping because it did the same to me. Sadly the sleep thing never went away for me even after 6 months. When I would go out I would take it right when I got home whether its 3Am or midnight and my doctor again said that was fine. With the latuda the food content isn't very important according to my doc but the 350 calories is very important. Sometimes I would forget to eat and I would get a really bad stomach ache for a few hours. The one thing I never got used to was the akasthesia I got a month after taking it