I take Zyprexa every day and Seroquel as needed. I tried stopping the Zyprexa and taking it PRN because I gained 40 pounds and it is impossible to lose the weight. I think it's worse because then I'm not used to it and it makes me really groggy the next day.

I've read that with atypicals the goal is to wean you off them after the mood stabilizer has kicked in, but it seems like a lot of people need to stay on them long term.