Absolutely when depressed. I did a lot of reading on the subject because I thought my T was trying to manipulate me (she wasn't she truly is a sweet heart). Being a chemistry student I went into the biochemistry of depression and the greatest relief for me was to read how depression literally changes the metabolism of the brain. It still sucks but it gave me the information that I am not a bad person or lazy because I am not "doing what I am supposed to" in order to feel better. I have come to terms with the fact that sometimes I literally do not have the energy to get out of bed. it is still a pain in the ***, but knowing that it not entirely my fault or that I am not sabotaging my progress is comforting.