The most I was ever on for bipolar at once was 5 I think (a couple of those were probably PRN for sleep and anxiety). I was never very comfortable with more than 3 on a regular basis, preferably 2. I'm also someone who has found menopause an apparent blessing for my bipolar symptoms. I've been med free pretty much from the time I realized I was entering menopause. Could be coincidence, but I think it definitely helped.