The first time I took Latuda I was at work (I work in a hospital so I get my meds from the pharmacy there) any who bad idea I was struggling to stay awake rest of the day. So after that I moved it to my 6:30pm meds after dinner. This was making me sick to my stomach so my pdocs nurse recommend taking with my bedtime meds at 8:30pm so I could just sleep through the nausea. Since then I haven't had any problems. I also normally judge a med after 3 - 4 weeks that way it can get to a therapeutic level in my body.