When I'm depressed, caffeine from coffee has no effect on me at all. But if I'm hypomanic or manic it makes me bouncing off the walls with energy, sometimes irritability and anxiety. I have a tendency to abuse coffee to get a manic high...which always leads to misery, eventually. I've never noticed caffeinated headache pills such as Excedrin Migraine causing me to feel more energetic...but then again, I only ever take them when I have a migraine which isn't very often. Personally, I think caffeine is fine in small doses unless you're manic...and bonus that it makes you feel less depressed.