Hi Mavenfp
I take Zoloft for anxiety/depression and have for several years. For me it took about 4 weeks to build up in my system before it started to help me. I always take Xanax on an as needed basis for extreme times of anxiety. I have been on Xanax several years on and off also...but more off then on. I am wondering if my Zoloft isn't working as well as it did before because I feel I am relying on Xanax more and more....when I go to my Pdoc next week I will ask what he thinks.

I hope the meds help you and that your body will tolerate it well.

Take care
Snow