Thanks for the feedback.

I find myself leaning towards Abilify, but then I also feel extremely lucky to have no serious side effects on Zyprexa, no rapid weight gain, no twitching, no sexual dysfunction, etc. It makes me hesitant to ditch it. I could wind up have serious side effects on Abilify, but can't know until I try. It feels like a big roll of the dice.

Then there is the element that Zyprexa works really well at reducing my agitation, but in addition to eliminating psychosis, that is about all it does really well. Abilify can probably bring more to the table in terms of depression symptoms, but one of its most commonly reported side effects is increased agitation. So it might wind up being like swapping out depression for severe agitation again.

So I am pretty torn on it. If I stick with Zyprexa, I know that I have agitation and psychosis covered, and could add something for depression and anxiety. But the idea of monotherapy is extremely appealing, less money and less medication, plus no issues as far medxmed interactions. Just not sure if I will be screwing up a good thing by switching.