I had depression from a very young age although it did not get severe until I was 16. A few decades have passed for me and I have still not exhausted all my options.

I have been reading a lot and it seems that genetics/biology is heavily involved in depression when it starts so young. For me there is a family history of persistent delressive disorder and no traumatic event or events occured to help make me this way. I was just depressed for no reason.

Despite this all the evidence points to therapy and medications. Therapy is especially useful I think for things like social rejection (i had and still have no friends). And obviously therapy is helpful elsewhere. There is HUGE evidence base for that. Medications its true don't work for everyone. But the majority do find a combination or an individual medication that helps. There is no cure but there is effective treatments. Now that is what the evidence says. I can back that up with studies. Exercise, fish oil, meditation, an active social life etc are important as well.

Your list of medications suggest something else is going on. What is your diagnosis?

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