I just came off Seroquel (400mg) very slowly I think two months ago. I'm only on lamictal for my bipolar, and several meds for anxiety and sleep. The sleeping is a huge issue, as I'm sure is for just about everyone. I'm very stable so far. I'm worried, but I know that I can go on Seroquel if need be. I should mention though that I do not have bipolar with psychosis.