Both saphris and Latuda showed weight gain in clinical trials. My problem is I work in a professional environment where suits are the norm. Ten pounds means I need a new wardrobe....I can't do that a third time! I have tried everything. Here is my fear: I try a drug gain 5 pounds and determine it isn't wait neutral. I try another one and the same thing happens. Now i am up ten! I am seriously about to give up on all this.