I wouldn't mess around like that, it's potent. I was on 400mg twice. A couple of years ago my incompetent pdoc took me off of it over a two week period and I instantly went into a mixed episode. A few months back, with the advice of my new pdoc, I came off of it over I think a three month period. I think every two weeks or so I went down 50mgs. It sucked. I felt like I had the flu for about three days every time, and I would feel a sense of being hypo for a period of time. Then when things would start to get better it was time to go down another 50. When I was done I could not sleep at all. My pdoc and I figured out a combination of meds to help, but it's not perfect. I think my sleep is going to be messed up forever, and it's been a couple of months now. There is no consistency, some nights are ok, and other nights are hell. My mood is stable just being on lamictal, but I don't have BP with psychosis like so many seem to have. I'm considering at my next appt. asking to go on 50mg of Seroquel, since I've heard the low doses help with sleep. I don't want to, but I'm sick of this up and down, I just want to sleep. So yes this does happen. Just be careful, like I said it can be hazardous messing with these meds.