I'm on 25 mg of Seroquel. I started at 300 mg and gradually was able to come down. The three times I've missed taking it over the past several months resulted in totally messed up sleep. Twice I lay awake for hours and the last time I did fall asleep but woke up after 3 hours......couldn't sleep after that. I didn't realize I missed the doses at the time until the next morning. (Sure enough the pill was still in the cup.) I don't expect to ever sleep normally without it, but I don't plan to. Along with Lamictal, Seroquel kept me stable for several years.