I had been on 60 mg of Cymbalta for a couple months, went up to 90 due to continuing depression issues and started having myoclonic jerks in my legs and arms. I went back down to 60 mg, and she added on 150 mg of Wellbutrin. I still kept having some issues with the myoclonus (though a bit less), so she decided to taper me off Cymbalta and onto Zoloft, which I'd been on in the past. She dropped me to 30 mg of Cymbalta for 2 weeks while I got up to 50 mg of Zoloft, while staying on the Wellbutrin. I stopped the Cymbalta a couple days ago. (I'll next go up to 75 mg of Zoloft, then maybe 100.)

She says I shouldn't have any Cymbalta withdrawal because the Zoloft is working on the serotonin and the Wellbutrin on the norepinephrine. However, the past few days, I've felt really on edge, and tonight I yelled at my husband about something fairly minor, which is very unlike me. (And no, it's not my time of the month!) I'm also pretty achy. Could this be Cymbalta withdrawal?

Note that I saw p-doc today, which is when she said I shouldn't be having withdrawal symptoms. If it continues over the weekend, I'll call her Monday.