Yes, it absolutely can. That's been my experience. Depression is not exactly the same for each person, so you may get a different opinion from someone else. Not only is depression not the same for each person, one depressive episode may be very different from another one for the same person.

What's definite, though, is that your thinking and emotions are not working normally when you're severely depressed. I tend to not trust my emotions when I'm very depressed, and try to put off making any kind of important decision, if I can, until I'm doing better. (I only came to that conclusion after making some disastrous decisions while depressed.)

Are you seeing a psychiatrist for your medication management? Your depression sounds very severe the way you've described it. You need someone who is well-acquainted with psychoactive drugs and how to prescribe them, so if you were prescribed the Wellbutrin by a primary care doctor, I'd look into trying to see a psychiatrist.

I'm glad that you've posted here at Psych Central. It's a good, supportive forum for talking about your depression and medication and for asking questions.