I came off of 400mg of Seroquil probably four or so months ago. I instantly could not sleep. Pdoc put me on Clonidine, Trazadone and Vistaril and I'm still having problems. I wake up several times a night, sometimes every half an hour. He won't up the doses. I don't know what to do. I think that having BP just causes sleep issues for most, and those stupid APs help. Good luck.