My experience has been that Seroquel at a very low dose acts very much like an antihistamine. The sedating effect fades as you go higher in dose, as do the headaches. Also, the anti-anxiety properties didn't kick in for me until I got to a much higher dose.

Regarding Abilify vs Seroquel costs, it's probably the difference between brand name vs generic. Abilify just went generic, but my pdoc says there are issues with the generic and he's still prescribing me the brand name. Abilify has a discount card that you can use for $5 co-pay if your insurance doesn't cover it...just ask your doc about it.

Seroquel has worked well for me for anxiety and mixed states, and Abilify was added to help with depression.