Kim,

These are the ones that most concern me

This is the information on Effexor XR and Effexor.

Brain disease or damage, or mental retardation or
Seizures (history of)—The risk of seizures may be increased

Heart disease or
High or low blood pressure—Venlafaxine may make these conditions worse

Kidney disease or
Liver disease—Higher blood levels of venlafaxine may occur, increasing the chance of side effects; your doctor may need to adjust your venlafaxine dose

Mania (history of)—The risk of developing mania may be increased

Weight loss—Venlafaxine may cause weight loss; this weight loss is usually small, but if a large weight loss occurs, it may be harmful in some patients

What exactly does that mean? that there is a chance to get mania, liver diease etc, or is this just mean that if you are already suffering from them that the medications could make them worse?